Hexosamine Pathway Induces Cardiac Arrhythmia via Modulation of Sustained Potassium Currentmodulation of Sustained Potassium Current

Poisoning with sustained release potassium.

Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia

Patients with chronic kidney disease (CKD) have a high risk of hyperkalemia, which increases mortality and can lead to renin-angiotensin-aldosterone system inhibitor (RAASi) dose reduction or discontinuation. Patiromer, a nonabsorbed potassium binder, has been shown to normalize serum potassium in patients with CKD and hyperkalemia on RAASi. Here, patiromer's onset of action was determined in p...

Bis(3)-tacrine inhibits the sustained potassium current in cultured rat hippocampal neurons.

Bis(3)-tacrine is a dimeric AChE inhibitor derived from tacrine with a potential to treat Alzheimer's disease. It was recently been reported to act as a fast off-rate antagonist of NMDA receptors with moderate affinity. In the present study, we aimed to explore whether bis(3)-tacrine could modulate the function of native sustained potassium current in cultured rat hippocampal neurons using whol...

Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia.

About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K+ channels are primarily responsible for early repolarization, whereas others drive late repolarization and still others are open throughout the cardiac cycle. Three main K+ channels drive the late repolarization of the ventricle with some redundancy, and in atria this repolarization res...

Relation between coronary sinus plasma potassium and cardiac arrhythmia.

IT APPEARS to be rather widely accepted that ventricular fibrillation very often follows premature ventricular beats occurring singly, or more often in a rapid series. The premature beat is most likely to lead to fibrillation if it occurs during repolarization of the ventricle (vulnerable period)." The extra systoles resulting from coronary occlusion can well be the cause of the ventricular fib...